Top 10 Small-Cap Biotechs with Upcoming Catalysts for 2025

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Here are 10 small cap biotech stocks with notable upcoming catalysts in 2025—ranging from trial readouts and FDA decisions to pivotal data and corporate milestones:
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🔬 Top 10 Small-Cap Biotechs with Upcoming Catalysts for 2025
1. Crinetics Pharmaceuticals (NASDAQ: CRNX)
• Catalyst: FDA PDUFA deadline for paltusotine (oral acromegaly treatment) expected by September 25, 2025.
• Focused on endocrine diseases and advancing pipeline beyond acromegaly (en.wikipedia.org).
Stock market information for Crinetics Pharmaceuticals Inc (CRNX)
• Crinetics Pharmaceuticals Inc is a equity in the USA market.
• The price is 32.33 USD currently with a change of -0.73 USD (-0.02%) from previous close.
• The latest open price was 33.1 USD and the intraday volume is 420639.
• The intraday high is 33.34 USD and the intraday low is 32.32 USD.
• The latest trade time is Wednesday, June 11, 23:45:00 +0300.
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2. Viking Therapeutics
• Catalyst: Late-stage trial start for injectable weight-loss drug (GLP 1/GIP); mid-stage data readout for oral candidate due in 2025 (barrons.com).
• Strong analyst sentiment: Jefferies forecasts ~223% upside
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3. Insmed (NASDAQ: INSM)
• Catalyst: Phase III/inhalable powder treprostinil palmitil for pulmonary arterial hypertension; recent results exceeded expectations; full Phase III data due in 2025
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4. Kymera Therapeutics
• Catalyst: Phase I for KT 621 (oral STAT6 degrader for dermatitis/asthma); next-stage readouts expected late 2025–early 2026
• Shares rose ~50% on initial results; further trials underway
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5. Arcutis Biotherapeutics (NASDAQ: ARQT)
• Catalyst: Technical breakout potential near $17.75; continued quarterly readouts with rising sales (33% last quarter)
• Upcoming investor calls/publication strategies may accelerate momentum.
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6. Rhythm Pharmaceuticals (NASDAQ: RYTM)
• Catalyst: With FDA-approved Imcivree for genetic obesity, further label expansion or mid-to-late-stage trial results anticipated in 2025
• Institutional buying trends and revenue growth support upcoming readouts .
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7. BeOne Medicines (Ticker: ONC)
• Catalyst: Early human data in solid tumor oncology; multiple upcoming trials in 2025 .
• Q1 2025 marked first profit; strong institutional support
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8. Mesoblast Ltd & Capricor Therapeutics
• Catalyst: Stem-cell therapies targeting GvHD, heart failure, Duchenne muscular dystrophy—key FDA decisions expected in H2 2025
• Maxim Group flags pivotal year for approvals and stock catalysts (marketwatch.com).
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9. Acelyrin (NASDAQ: SLRN)
• Catalyst: Phase III results for lonigutamab in thyroid eye disease; shareholder vote on Alumis merger around May 2025
• Merger closing and clinical readouts may drive volatility .
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10. ADC Therapeutics & Foghorn Therapeutics & Pyxis Oncology
• Catalysts: Multiple preclinical/early clinical updates presented at AACR (April 2025)
o ADC Therapeutics (ADCT): Readouts on 6 ADC programs (Claudin 6, NaPi2b, etc.).
o Foghorn (FHTX): Preclinical updates on EP300, FHD609, FHD909.
o Pyxis Oncology (PYXS): Phase I ADC and Siglec 15 antibody data.
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🔎 How to Monitor These Catalysts
• FDA PDUFA dates (Crinetics, Mesoblast/Capricor, Viking)
• Trial readouts/ASC presentations (Kymera, Insmed, ADC Therapeutics, Foghorn, Pyxis)
• M&A/news events (BeOne, Acelyrin merger)
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📊 Summary Table
Ticker Company Upcoming Catalyst Timeframe
CRNX Crinetics PDUFA paltusotine NDA Sep 25, 2025
Viking Viking Therapeutics Injectable Phase III, oral Phase II data From mid-2025
INSM Insmed PAH inhalable Phase III readout Mid-to-late 2025
Kymera Kymera Therapeutics Dermatitis/asthma Phase I → Phase II Late 2025 – 2026
ARQT Arcutis Biotherapeutics Continued quarterly updates Throughout 2025
RYTM Rhythm Pharmaceuticals Label expansion/trial updates 2025
ONC BeOne Medicines Solid tumor trial data 2025
Mesoblast/Capricor Stem-cell stocks FDA decisions H2 2025
SLRN Acelyrin EMA/merger vote + Phase III readout May–Q3 2025
ADCT/FHTX/PYXS AACR presenters Academic readouts on multiple programs April 2025
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⚠️ A Word of Caution
Small-cap biotech involves high volatility—catalyst events often drive sharp price swings, both up and down. Thorough due diligence is essential.

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